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Gerd Geisslinger Selected Research

Drug Therapy (Chemotherapy)

6/2023SAFit2 ameliorates paclitaxel-induced neuropathic pain by reducing spinal gliosis and elevating pro-resolving lipid mediators.
10/2022SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain.
1/2019GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.
1/2019Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.
1/2019Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001.
10/2018Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.
1/2018Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.
2/2017SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
1/2017The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity.
11/2016Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.
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Gerd Geisslinger Research Topics

Disease

104Pain (Aches)
12/2023 - 01/2002
75Inflammation (Inflammations)
02/2024 - 03/2003
53Neoplasms (Cancer)
01/2024 - 04/2003
42Neuralgia (Stump Neuralgia)
06/2023 - 02/2004
40Hyperalgesia
04/2020 - 10/2002
24Hypersensitivity (Allergy)
10/2023 - 08/2005
14Chronic Pain
08/2023 - 06/2005
12Multiple Sclerosis
01/2021 - 12/2007
10Carcinoma (Carcinomatosis)
01/2021 - 07/2003
10Breast Neoplasms (Breast Cancer)
10/2020 - 11/2008
9Colonic Neoplasms (Colon Cancer)
01/2024 - 07/2003
9Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
10/2018 - 06/2012
8Infections
08/2021 - 05/2002
7Edema (Dropsy)
01/2023 - 03/2003
7Atherosclerosis
10/2019 - 07/2004
7Peripheral Nerve Injuries
10/2014 - 05/2010
6Mental Disorders (Mental Disorder)
08/2023 - 06/2011
6Wounds and Injuries (Trauma)
10/2022 - 05/2003
6Alzheimer Disease (Alzheimer's Disease)
01/2022 - 12/2007
6Colitis
07/2019 - 02/2007
5COVID-19
02/2024 - 01/2021
5Asthma (Bronchial Asthma)
01/2019 - 12/2007
5Fever (Fevers)
01/2018 - 07/2006
5Hepatitis C
01/2015 - 01/2010
5Nausea
10/2013 - 01/2002
4Colorectal Neoplasms (Colorectal Cancer)
01/2024 - 04/2003
4Fibrosis (Cirrhosis)
06/2023 - 12/2014
4Acute Pain
01/2023 - 03/2007
4Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2019 - 01/2017
4Osteoarthritis
07/2014 - 03/2003
4Myocardial Infarction
06/2012 - 01/2004
4Respiratory Insufficiency (Respiratory Failure)
09/2006 - 10/2003
3Melanoma (Melanoma, Malignant)
12/2023 - 01/2014
3Neuroinflammatory Diseases
06/2023 - 01/2011
3Hemorrhage
01/2023 - 01/2004
3Type 2 Diabetes Mellitus (MODY)
01/2022 - 10/2008
3Neurodegenerative Diseases (Neurodegenerative Disease)
08/2021 - 07/2004
3Autoimmune Diseases (Autoimmune Disease)
01/2021 - 04/2013

Drug/Important Bio-Agent (IBA)

32LipidsIBA
02/2024 - 09/2007
26Analgesics (Analgesic Drugs)IBA
01/2023 - 01/2003
25ZymosanIBA
10/2023 - 03/2003
24Proteins (Proteins, Gene)FDA Link
02/2024 - 07/2004
19ProstaglandinsIBA
10/2023 - 05/2003
15EnzymesIBA
01/2024 - 09/2005
14CeramidesIBA
09/2021 - 05/2009
14Dinoprostone (PGE2)FDA Link
01/2021 - 05/2003
12SphingolipidsIBA
01/2024 - 11/2008
12Opioid Analgesics (Opioids)IBA
05/2013 - 01/2002
12Cyclooxygenase 2 (Cyclooxygenase-2)IBA
07/2011 - 04/2003
11Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
10/2023 - 01/2004
11Formaldehyde (Formol)FDA Link
01/2017 - 03/2003
10CytokinesIBA
12/2023 - 07/2007
10Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
11/2014 - 03/2003
10Celecoxib (Celebrex)FDA Link
12/2010 - 05/2003
10Morphine (MS Contin)FDA LinkGeneric
11/2010 - 10/2002
8dihydroceramide desaturaseIBA
01/2024 - 06/2012
8Capsaicin (Zostrix)FDA Link
11/2022 - 11/2008
8Reactive Oxygen Species (Oxygen Radicals)IBA
11/2021 - 01/2011
8Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2020 - 11/2006
8Epoxide HydrolasesIBA
01/2019 - 02/2009
8Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
10/2009 - 05/2003
7ChemokinesIBA
02/2024 - 05/2012
7Phosphotransferases (Kinase)IBA
11/2021 - 10/2008
7Messenger RNA (mRNA)IBA
10/2020 - 09/2011
7Biomarkers (Surrogate Marker)IBA
01/2019 - 02/2008
7Prostaglandins EIBA
04/2012 - 04/2008
6EndocannabinoidsIBA
09/2021 - 11/2007
6NF-kappa B (NF-kB)IBA
04/2010 - 04/2003
5Epoprostenol (Prostacyclin)FDA LinkGeneric
04/2022 - 05/2005
5Fingolimod Hydrochloride (FTY720)FDA Link
03/2022 - 02/2007
5G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2022 - 07/2013
5sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
09/2021 - 10/2007
5Cytostatic AgentsIBA
12/2020 - 12/2014
5Ion Channels (Ion Channel)IBA
12/2020 - 02/2011
5ThromboxanesIBA
01/2019 - 03/2007
5Antiviral Agents (Antivirals)IBA
10/2018 - 01/2010
5Flurbiprofen (Froben)FDA LinkGeneric
12/2016 - 07/2003
5Protein Isoforms (Isoforms)IBA
11/2016 - 04/2003
5GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA
02/2013 - 11/2006
4Transcription Factors (Transcription Factor)IBA
08/2021 - 03/2007
4LipopolysaccharidesIBA
01/2021 - 01/2011
4sphingosine kinaseIBA
01/2021 - 11/2008
4Protein Kinases (Protein Kinase)IBA
01/2019 - 03/2003
4Sphingosine-1-Phosphate ReceptorsIBA
01/2019 - 05/2009
4Fatty Acids (Saturated Fatty Acids)IBA
01/2019 - 11/2007
4Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA
10/2018 - 06/2014
4Cyclooxygenase InhibitorsIBA
03/2014 - 05/2003
4rofecoxib (Vioxx)FDA Link
10/2009 - 03/2003
4Cyclooxygenase 1IBA
08/2009 - 05/2003
4mu Opioid Receptors (mu Opioid Receptor)IBA
06/2009 - 01/2003
3SAFit2IBA
06/2023 - 10/2022
3Paclitaxel (Taxol)FDA LinkGeneric
06/2023 - 06/2015
3Glucose (Dextrose)FDA LinkGeneric
01/2022 - 01/2020
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2022 - 05/2008
3NucleosidesIBA
10/2021 - 05/2011
3Cytarabine (Cytosar-U)FDA LinkGeneric
10/2021 - 01/2017
3sapropterin (tetrahydrobiopterin)FDA Link
01/2021 - 11/2006

Therapy/Procedure

46Therapeutics
06/2023 - 11/2002
12Drug Therapy (Chemotherapy)
06/2023 - 12/2014
7Analgesia
11/2013 - 05/2003